Oswaldo Keith Okamoto

Oswaldo Keith Okamoto

Oswaldo Keith Okamoto is an Associate Professor in the Department of Genetics and Evolutionary Biology at the University of São Paulo. Previously, he was a Professor of Neurosciences at the Medical School of the Federal University of São Paulo (2006-2010). Dr. Okamoto earned his B.Sc. degree in biological sciences at the São Paulo State University in 1994, and a Ph.D. in Biochemistry and Molecular Biology at the University of São Paulo in 2000. From 2000 to 2003, he conducted research as a postdoctoral fellow in the Department of Molecular and Cellular Biology at Harvard University. Before his first appointment as a professor in Brazilian academia, Dr. Okamoto worked from 2003 to 2006 as senior researcher and scientific coordinator of the Experimental Research Center at the Albert Einstein Education & Research Institute in São Paulo. His current research focuses on the interplay between stem cell biology and cancer, with emphasis on the genetic and molecular mechanisms inducing a stem cell-like phenotype in cancer cells, their role in tumor heterogeneity and aggressiveness, and the contribution of normal stem cells to tumor development and metastasis. Preclinical therapy studies for cancer and some neurological disorders comprise another major scientific interest of his group.

 

Selected publications:

  1. Rocha CR, Lerner LK, Okamoto OK, Marchetto MC, Menck CF. The role of DNA repair in the pluripotency and differentiation of human stem cells. Mutat Res. 2013 Jan-Mar;752(1):25-35.
     
  2. Vessoni AT, Muotri AR, Okamoto OK. Autophagy in stem cell maintenance and differentiation. Stem Cells Dev. 2012 Mar 1;21(4):513-20.
     
  3. Rodini CO, Suzuki DE, Saba-Silva N, Cappellano A, de Souza JE, Cavalheiro S, Toledo SR, Okamoto OK. Expression analysis of stem cell-related genes reveal OCT4 as a predictor of poor clinical outcome in medulloblastoma. J Neurooncol. 2012 Jan;106(1):71-9.
     
  4. Okamoto OK, Oba-Shinjo SM, Lopes L, Nagahashi Marie SK. Expression of HOXC9 and E2F2 are up-regulated in CD133(+) cells isolated from human astrocytomas and associate with transformation of human astrocytes. Biochim Biophys Acta. 2007 Jul-Aug;1769(7-8):437-42.
     
  5. Pereira MC, Secco M, Suzuki DE, Janjoppi L, Rodini CO, Torres LB, Araújo BH, Cavalheiro EA, Zatz M, Okamoto OK. Contamination of mesenchymal stem-cells with fibroblasts accelerates neurodegeneration in an experimental model of Parkinson’s disease. Stem Cell Rev. 2011 Nov;7(4):1006-17.
     
  6. Okamoto OK, Janjoppi L, Bonone FM, Pansani AP, da Silva AV, Scorza FA, Cavalheiro EA. Whole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis. BMC Genomics. 2010 Apr 8;11:230.
     
  7. Secco M, Moreira YB, Zucconi E, Vieira NM, Jazedje T, Muotri AR, Okamoto OK, Verjovski-Almeida S, Zatz M. Gene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood. Stem Cell Rev.2009 Dec;5(4):387-401.
     
  8. Okamoto OK, Perez JF. Targeting cancer stem cells with monoclonal antibodies: a new perspective in cancer therapy and diagnosis. Expert Rev Mol Diagn. 2008 Jul;8(4):387-93.
     
  9. Marie SK, Okamoto OK, Uno M, Hasegawa AP, Oba-Shinjo SM, Cohen T, Camargo AA, Kosoy A, Carlotti CG Jr, Toledo S, Moreira-Filho CA, Zago MA, Simpson AJ, Caballero OL. Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas. Int J Cancer. 2008 Feb 15;122(4):807-15. PubMed PMID: 17960622.
     
  10. Secco M, Zucconi E, Vieira NM, Fogaça LL, Cerqueira A, Carvalho MD, Jazedje T, Okamoto OK, Muotri AR, Zatz M. Multipotent stem cells from umbilical cord: cord is richer than blood! Stem Cells. 2008 Jan;26(1):146-50.