Dr. Carlos Frederico Martins Menck

Dr. Carlos Frederico Martins Menck

Dr. Menck earned his B.Sc. in Biological Sciences at the Institute of Biosciences of the University of Sao Paulo (IBUSP) in 1977 and his Ph.D. in Biochemistry at the Chemistry Institute of USP (1982). He worked as Assistant Professor at the Biology Institute of UERJ from 1982 to 1985, before proceeding to do postdoctoral work at the Laboratory of Genomic Instability, under Dr. Alain Sarasin, at the Institute for Cancer Research (CNRS, Villejuif, France). Upon returning to Brazil in 1986, he joined the Biology Department of IBUSP. In 1996 he became full Professor of the Department of Microbiology of Institute of Biomedical Sciences, USP, where he teaches and conducts research.
He was elected titular member of the Brazilian Academy of Sciences in 2005 and in 2007 became “Member of the National Order of Scientific Merit”. His main research interests are molecular DNA repair mechanisms and mutagenesis. He has published 137 research papers, 24 book chapters and also essays. At the Human Genome Center he collaborates in research projects involving DNA repair and ageing diseases, besides contributing his knowledge of virus-derived genetic vectors.

 

Research Interests
Dr. Menck collaborates in research projects involving DNA repair and ageing diseases, besides contributing his knowledge of virus-derived genetic vectors. The DNA Repair Group seeks to understand cellular responses after induced genome lesions, and how these responses lead to neurodegeneration, ageing, and carcinogenesis. Knowledge of these processes can help minimize the deleterious effects of DNA damage in humans, or even help establish therapeutic protocols for cancer.
The initial approach for studying these processes consists in transferring genes to DNA repair-deficient cells. To achieve this, our group has developed adenovirus-derived vectors with DNA repair genes, capable of correcting cellular defects in xeroderma pigmentosum cells (a DNA repair deficiency syndrome). We also investigate mechanisms that make tumor cells resistant to DNA damaging chemotherapeutic drugs. This approach aims to develop methods capable of improving the drug’s efficiency in deterring tumor growth via specific gene silencing using RNA interference. On the long run, we plan to develop processes capable of improving the efficiency of anti tumor drugs on cancer therapy.

 

Other Activities
Dr. Menck is involved mainly with research, without participating in diagnostic or counseling services. Nonetheless, the group will perform cellular and molecular tests for xeroderma pigmentosum, if patient DNA samples (from blood or saliva) are available.

 

10 favourites publications

  1. Batista LF, Kaina B, Meneghini R, Menck CF (2009) How DNA lesions are turned into powerful killing structures: Insights from UV-induced apoptosis. Mutat Res Reviews, 681(2-3):197-208.
     
  2. Lima WC, Varani AM and Menck CF (2009) NAD biosynthesis evolution in bacteria: lateral gene transfer of kynurenine pathway in Xanthomonadales and Flavobacteriales. Molecular Biology of Evolution, 26(2): 399-406.
     
  3. Leite, RA, Marchetto, MC, Muotri, AC, Vasconcelos, DM, Oliveira, ZNP, Machado MCR, Menck, CF (2009) Identification of XP complementation groups by recombinant adenovirus carrying DNA repair genes. Journal Investigative Dermatology, 129(2):502-506.
     
  4. Batista LF, Roos WP, Kaina B and Menck CF (2009) p53 mutant human glioma cells are sensitive to UV-C induced apoptosis due to impaired CPD removal. Molecular Cancer Research 7(2): 237-246.
     
  5. Cutiño-Jiménez AM, Martins-Pinheiro M, Lima WC, Martín-Tornet A, Morales OG, Menck CFM (2010) Evolutionary placement of Xanthomonadales based in conserved protein signature sequences. Molecular Phylogenetics and Evolution, 54: 524-534.
     
  6. Moraes, MCS, Cabral-Neto, JB, Menck, CFM (2012) DNA repair mechanisms protect our genome from carcinogenesis. Frontiers in Bioscience, 17: 1362-1388.
     
  7. Moraes MC, Andrade AQ, Carvalho H, Guecheva T, Agnoletto MH, Henriques JA, Sarasin A, Stary A, Saffi J, Menck CF (2012). Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions. Cancer Lett. 314: 108-118.
     
  8.  Schuch AP, Lago JC, Yagura T, Menck CF ( 2012) DNA dosimetry assessment for sunscreen genotoxic photoprotection. PLoS One. 7(6):e40344.
     
  9. Rocha CR, Lerner LK, Okamoto OK, Marchetto MC, Menck CF (2013) The role of DNA repair in the pluripotency and differentiation of human stem cells. Mutat Res, Reviews in Mutat Res, 752:15-28.
     
  10. Soltys DT, Rocha CR, Lerner LK, de Souza TA, V Munford, F Cabral, Nardo T, Stefanini M, Sarasin A, Cabral-Neto JB, Menck CFM (2013) Novel XPG (ERCC5) mutations affect DNA repair and ell survival after ultraviolet but not oxidative stress. Human Mutation, 34 (3): 481-489.